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How methodological pitfalls have created widespread misunderstanding about long COVID

The existing epidemiological research on long COVID has suffered from overly broad case definitions and a striking absence of control groups, which have led to distortion of risk. The unintended ...
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Diet–heart disease hypothesis is unaffected by results of analysis of recovered data from Minnesota Coronary Experiment

Correspondence to: Professor Murray Skeaff, Department of Human Nutrition, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand; murray.skeaff{at}otago.ac.nz If you wish to reuse any or all of ...
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Estimates of the minimal important difference to evaluate the clinical significance of antidepressants in the acute treatment of moderate-to-severe depression

The efficacy of antidepressants in the acute treatment of moderate-to-severe depression remains a controversial issue. The minimal important difference (MID) is relevant to judge the clinical ...
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Using Risk of Bias 2 to assess results from randomised controlled trials: guidance from Cochrane

Correspondence to Dr Kerry Dwan, Centre for Reviews and Dissemination, University of York, York, UK; Kerry.dwan{at}york.ac.uk A systematic review identifies, appraises and synthesises all the ...
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077 How can shared decision-making turn into paternalism – and how should we think about this ethically?

Introduction When a health professional overrides a patient’s preferences for the patient’s own good, we have a case of paternalism. Paternalism is commonly considered ethically problematic and ...
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Reconsidering the role of tramadol in chronic pain management

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be ...
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EBM Guidelines: Evidence-Based Medicine

This electronic resource aims to provide physicians with fast and easy access to practical guidelines linked to the best available research evidence. It covers a wide range of medical conditions and ...
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Superiority trials: raising the bar of null hypothesis statistical testing

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be ...
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Adherence to the Guideline for Reporting Evidence-based practice Educational interventions and Teaching (GREET) of studies on evidence-based healthcare e-learning: a cross ...

Correspondence to Dr Tina Poklepović Peričić, Department of Research in Biomedicine and Health, University of Split School of Medicine, Split, Croatia; tinapoklepovic{at}gmail.com Objectives The ...
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Early experience with the FDA’s regulatory review of novel gene therapies

Correspondence to Dr Jeremy Puthumana, Yale University School of Medicine, New Haven, Connecticut, USA; jeremy.puthumana{at}yale.edu Contributors JP and JR drafted the manuscript. JP and ACE acquired ...
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Making care fit manifesto

Correspondence to Dr Marleen Kunneman, Medical Decision Making, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands; kunneman{at}lumc.nl For too many people, ...
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79 The impact of orthodontic treatment regulation in the german public health sector on the overuse of orthodontic services

Objectives The provision of orthodontic (dental) care is part of the German Public Health sector comprising 90% of German population. The current regulations for the provision of orthodontic care in ...