NFL Week 16 odds & picks
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You can also see the model's best bets for every Week 15 NFL game. Finally, SportsLine expert RJ White, who is 141-120-5 (+1421) over his last 266 NFL picks, has locked in multiple Week 15 NFL picks. Visit SportsLine to see his best bets.
Who will end up where in the 2025 NFL playoff picture remains anyone's guess but after a Week 15 of high-stakes games, we have our first two teams to clinch a spot in the dance.
The Los Angeles Chargers have consecutive outright wins as an underdog, while the Dallas Cowboys have lost outright in back-to-back games as a favorite. Los Angeles has also won six of seven to improve to 10-4 for the campaign, while Dallas is all but officially eliminated from the postseason at 6-7-1.
Model's Jets vs. Jaguars score prediction, picks. Rather understandably, the Jaguars are enormous favorites. New York wins in just 19% of the SportsLine Proj
6don MSN
NFL Week 15 betting, odds, lines: 5 biggest storylines, including Lamar Jackson's disappearing act
The Rams won big in Week 14, and that was important for Matthew Stafford's MVP odds. Stafford is back to being the betting favorite to win MVP after throwing for 281 yards and three touchdowns in a 45-17 blowout of the Cardinals. Stafford is -175 to win MVP. Drake Maye, last week's favorite who had a bye in Week 14, is +200.