DNA replication is a fundamental process essential for bacterial growth and survival. Initiation begins at the chromosomal origin (oriC), where the conserved initiator protein DnaA assembles into an ...
A clearer understanding of the origin recognition complex (ORC) - a protein complex that directs DNA replication - through its crystal structure offers new insight into fundamental mechanisms of DNA ...
(Nanowerk News) A clearer understanding of the origin recognition complex (ORC) – a protein complex that directs DNA replication – through its crystal structure offers new insight into fundamental ...
Eukaryotic RNA polymerase I (Pol I) is specialized in rRNA gene transcription synthesizing up to 60% of cellular RNA. High level rRNA production relies on efficient binding of initiation factors to ...
Using single-molecule DNA nanomanipulation, we show that abortive initiation involves DNA "scrunching"--in which RNA polymerase (RNAP) remains stationary and unwinds and pulls downstream DNA into ...
Every living cell transcribes DNA into RNA. This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA. Within a few hundred milliseconds, the DNA double helix unwinds to form a ...
Scientists have uncovered how DnaA, the master key to DNA replication, opens the door to bacterial growth. This breakthroughpaves the way for new antibiotics to combat the rising tide of antibiotic ...
Kazunori Tachibana, Masashi Mori, Takashi Matsuhira, Tomotake Karino, Takuro Inagaki, Ai Nagayama, Atsuya Nishiyama, Masatoshi Hara, Takeo Kishimoto, Joan Ruderman Proceedings of the National Academy ...
Solution to duplicating the eukaryotic genome 3 billion bps in the human genome. About 50,000 replication origins/genome. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news ...
How chronic inflammation results in DNA damage and hypomethylation associated with cancer initiation
A new study led by researchers at Queen Mary University of London describes how chronic inflammation leads to altered, tumour-like epigenetic state and the re-expression of ancient, gene-editing ...
In this multi-disciplinary work employing single-molecule TIRF microscopy, chemical biology and structural biology, Dr Aravindan Ilangovan, Reader in Structural Biology, and his team at School of ...
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