The Niners were fresh off a roster revamp, saying goodbye to nearly 20 players in the offseason, 15 of whom landed deals elsewhere worth up to a maximum of $341.5 million. In their place, the 49ers leaned into their youth, with an 11-man draft class and a free agent group that had no marquee players.

In Week 6, Malik Mustapha came back. The 49ers used Sigle in a platoon with Mustapha for two games, but once Mustapha took his role back over, there were no more snaps for Sigle. The 49ers move Ji’Ayir Brown into the starting lineup and slide Jason Pinnock into the nickel, making Sigle the fourth safety.

Sights and sounds that would have been unimaginable in the heyday of the Giants-49ers rivalry left Jon Runyan Jr. with a pit in his stomach.

The San Francisco 49ers will be getting some players back against the Los Angeles Rams, but their superstar WR remains out of action.

The San Francisco 49ers have a handful of injured starters who could return when the Los Angeles Rams visit Levi's Stadium in Week 10.

San Francisco 49ers receiver Brandon Aiyuk is still unable to practice more than a year after his knee injury. Also sidelined is second-year receiver Ricky Pearsall.

The San Francisco 49ers have been winning games despite significant injuries to key players. On Sunday, first-round pick Mykel Williams suffered a season-ending knee injury in a victory over the New York Giants.